Journal: Neurology

Article Title: Seizure Detection in Continuous Inpatient EEG

doi: 10.1212/WNL.0000000000200267

Figure Lengend Snippet: Performance of Persyst 12 vs Persyst 13 Automated Seizure Detection

Article Snippet: Sensitivity of automated detection was higher for focal-onset seizures than for generalized-onset seizures (0.93 vs 0.85, p = 0.012, ). table ft1 table-wrap mode="anchored" t5 caption a7 Performance of Persyst 12 vs Persyst 13 Automated Seizure Detection Open in a separate window table ft1 table-wrap mode="anchored" t5 caption a7 Sensitivity of Automated Seizure Detection for Focal vs Generalized Seizures Open in a separate window Last, to further account for potential bias from repeated EEGs for some individuals in the cohort, we limited the analysis to only the first EEG recorded for each of 2,854 unique individuals.

Techniques:

Journal: Annals of Clinical and Translational Neurology

Article Title: Acute seizure suppression by transcranial direct current stimulation in rats

doi: 10.1002/acn3.226

Figure Lengend Snippet: Clinical and EEG outcomes of cathodal tDCS treatment. (A) GTCS incidence and latency after first PTZ injection. Kaplan–Meier survival curve is used to display percentage incidence of GTCS ( y -axis) and its latency ( x -axis), after first PTZ injection in all treatment conditions. The height of each step represents the percentage of rats experiencing a GTCS and the length of the curve represents the GTCS latency from the first myoclonus. The median latencies in the cath 1 mA and cath 0.1 mA groups, respectively, were not significantly longer than that of sham rats. Note the clustering of GTCS latencies <300 sec in most animals. (B) GTCS duration after first PTZ injection. The first PTZ injection induced one or multiple GTCS in most rats. There was no significant reduction in the median durations of seizures in cath 1 mA or cath 0.1 mA treatment groups relative to sham. (C) Representative EEG traces. Sample baseline EEG without epileptiform activity (1); Sample EEG after PTZ injection shows a characteristic automatically detected spike-train outlasting 1 sec (2). (D) Spike burst count after first PTZ injection. Graph depicts the number of EEG burst discharges per 10 min of recording after treatment with tDCS, as digitally counted using the seizure detection algorithm of Neuroscore (Data Sciences International, St. Paul, MN) and verified by visual inspection. The number of detected bursts was significantly lower in the rats that were stimulated by cathodal 1 mA treatment relative to sham controls or cathodal 0.1 mA. * P < 0.05. (E) GTCS incidence and latency after second PTZ injection. Kaplan–Meier survival curve is used to display percentage incidence of GTCS ( y -axis) and its latency ( x -axis), after second PTZ injection in all treatment conditions. Curve comparison shows that the GTCS incidence rate of 94% in sham group was significantly higher than the cath 1 mA (60%) and cath 0.1 mA (74%)-treated animals. Also the sham rats were the quickest to seize after second PTZ challenge as compared to the treatment groups. Note the clear separation in the Kaplan-Meier curve of cath 1 mA treatment group. (F) GTCS duration after second PTZ injection. The seizures caused by second PTZ injection were significantly of shorter duration in the cath 1 mA treatment group as compared to the sham-treated animals. Boxes indicate median and first and third quartile. Tukey’s error bars are indicated by top and bottom whiskers. An outlier value is indicated, beyond the Tukey’s error range by the solid circle. * P < 0.05. EEG, electroencephalography; tDCS, transcranial direct current stimulation; GTCS, generalized tonic-clonic seizures; PTZ, pentylenetetrazol.

Article Snippet: The epileptic spike bursts were counted by optimizing the automated seizure detection algorithm in Neuroscore (Data Sciences International, St. Paul, MN).

Techniques: Injection, Activity Assay, Comparison